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FDA approval means the medications dosage recommendation is safe and effective for what its being used for

In the year following discontinuation of semaglutide or liraglutide, patients with class 3 obesitya BMI of 40 or greaterwhen starting a GLP-1 medication were much more likely to maintain or lose additional weight compared to those who started treatment with a healthy weighta BMI between 18.5 and 25

Acamprosate helps a different minority

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Its also used in overweight adults (a BMI of 27 kg/m2 or greater) with at least one weight-related health condition, such as high blood pressure, high cholesterol, obstructive sleep apnea, or Type 2 diabetes